Comparative analysis for elucidation of pathogenic factors of group D streptococci involved in colon cancer.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08462
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: Kobe Institute of Health
• Principal Investigator: Nomoto Ryohei 神戸市環境保健研究所, その他部局等, 研究員 (60642238)
• Co-Investigator(Renkei-kenkyūsha): MARUYAMA Fumito 京都大学, 大学院・医学研究科, 準教授 (30423122)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ゲノム比較解析 / ゲノム関連解析 / 分子疫学 / 人獣共通感染症 / レンサ球菌

Outline of Final Research Achievements

In this study, we performed to comparative genomic analysis of Streptococcus gallolyticus (SG), which is suspected causative agent of an emerging zoonotic infectious disease and predicting a causal relationship with human colon cancer, for organizing the phylogenetic position and elucidating pathogenic factors. The whole genome information of all SG strains were obtained, and core genome analysis was performed. The phylogenetic analysis was shown that SG is a bacterium that can cause both of animal and human infection. We analysed for capsule biosynthesis gene cluster related to pathogenicity and found that there are 7 types. In addition, the adhesion to collagen and biofilm formation ability were evaluated, and the mechanism of SG forming endocarditis was clarified. We investigated the distribution of SG in the intestinal tract of humans and obtained knowledge on adaptation of SG to humans which was unknown so far.

Free Research Field

病原微生物学