2017 Fiscal Year Final Research Report
Development of a novel Shiga toxin inhibitor that targeting of intracellular transport of the toxin
| Project/Area Number |
15K08480
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Bacteriology (including mycology)
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
Takahashi Miho 同志社大学, 生命医科学部, 助教 (00446569)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 志賀毒素 / 細胞内小胞輸送 / ペプチド / 阻害剤 / ペプチドライブラリー |
|---|
| Outline of Final Research Achievements |
We synthesized substrate peptides of various kinases on a slide glass and using this, we analyzed the activities of kinases stimulated by Stx1a in the presence or absence of Stx inhibitors (MMA-tet, FRA-tet).We established a new multivalent peptide library screening by using tetravalent peptides synthesized on a cellulose membrane.
|
| Free Research Field |
細胞生物学
|
