Dynamics of clinically derived drug-resistant plasmid by plasmid network analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08488
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Yamashita Akifumi 国立感染症研究所, 病原体ゲノム解析研究センター, 主任研究官 (00573180)
• Research Collaborator: KURODA MAKOTO 国立感染症研究所, 病原体ゲノム解析研究センター, センター長 (80317411)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: プラスミド / 薬剤耐性 / ネットワーク解析 / バイオインフォマティクス / 臨床由来株

Outline of Final Research Achievements

In this study, we created a web application named open iPAT to explore the relationship of plasmids in a bird's-eye view by using network analysis techniques by utilizing the fact that related plasmids share genes of the same origin. The open iPAT enabled not only to display related plasmids registered in the public database on the network diagram, but also to display the list of drug resistance genes, incompatibility typing, collected countries, hosts, collection year, etc. In addition, we implemented a function to graphically display the results by pangenomic analysis and core genome analysis, making it possible to analyze the relationship of plasmids in detail.

Free Research Field

バイオインフォマティクス