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2017 Fiscal Year Final Research Report

Control of Chronic Liver Diseases due to Hepatitis C Virus by Long Non-coding RNAs

Research Project

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Project/Area Number 15K08492
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Virology
Research InstitutionKanazawa University

Principal Investigator

Shimakami Tetsuro  金沢大学, 附属病院, 特任教授 (50436820)

Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsC型肝炎ウイルス / 長鎖ノンコーディングRNA
Outline of Final Research Achievements

We investigated the role of long non-coding RNAs in HCV infection. The analysis on RNA of HCV-infected cultured hepatocytes by a next generation sequencer revealed that the RNA level of one of long non-coding RNAs, HULC, increased. The increase of HULC RNA level was observed not only in HCV-infected cultured hepatocytes, but also in an HCV-infected chimpanzee and a HCV-infected mouse. The knockdown of HCV by siRNA suppressed HCV replication as well as infectious virus production in HCV-infected cultured hepatocytes. This effect seemed to occur through the suppression of a translation step among HCV life cycles. Several recent reports show that HULC has the ability to promote hepatocarcinogenesis, therefore, the result of this study suggests a mechanism of hepatocarcinogesis due to HCV infection through HULC.

Free Research Field

肝臓病学

URL: 

Published: 2019-03-29  

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