Study on the regulatory mechanisms of infectious particle formation of hepatitis C virus by arachidonic acid cascade

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Kyoto University
• Principal Investigator: Hjijikata Makoto 京都大学, ウイルス・再生医科学研究所, 准教授 (90202275)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: C型肝炎ウイルス / 感染性粒子産生 / アラキドン酸カスケード / トロンボキサン合成酵素 / 阻害剤

Outline of Final Research Achievements

Molecular Mechanisms for the inhibition of infectious hepatitis C virus particle formation by thromboxane A2 synthase inhibitor, Oxagrel, was examined in detail by several techniques. Microarray and CAGE analyses have showed no informative result. Metabolite study, however, showed that the reduction of hexanoic acid (HA), a fatty acid with pentatonic carbon chain, was caused in the cells treated with Oxagrel. The contribution of HA to the infectious HCV particle formation was not cleared yet. It seemed to be a novel finding that the amount of HA in the cells was changed by TXAS inhibitor.

Free Research Field

ウイルス学