2017 Fiscal Year Final Research Report
Studies on the molecular mechanism of cell-entry inhibitors for hand-foot-and-mouth disease virus.
| Project/Area Number |
15K08512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 手足口病 / エンテロウイルス71 / 受容体 / PSGL-1 / ヘパラン硫酸 / 感染阻害剤 |
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| Outline of Final Research Achievements |
Enterovirus 71 (EV71) is one of the pathogens of hand, foot, and mouth disease and various neurological symptoms including fatal encephalitis in young children. There are no specific therapies available. In this study, I focused on the anti-EV71 compound, NF449. I clarified how NF449 inhibits EV71 replication in vitro. I found that NF449 interacts with the EV71 capsid and prevents virus attachment to the receptor molecules on the cell surface. This work provides information that may facilitate development of improved antiviral compounds that block the attachment of EV71 to cellular receptors.
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| Free Research Field |
ウイルス学
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