2017 Fiscal Year Final Research Report
Regulation of the immunological function by the CD47-SIRP alpha signaling system
| Project/Area Number |
15K08532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 樹状細胞 / ストローマ細胞 / SIRPα / CD47 |
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| Outline of Final Research Achievements |
We have here investigated the regulatory mechanism of the immune system, especially of dendritic cell function by the CD47-SIRPα signaling system. We have shown that both SIRPα and CD47 on dendritic cells regulate homeostasis of SIRPα+ dendritic cells in lymphoid organs. Moreover, these molecules regulate homeostasis of stromal cells in the spleen through the production of TNF receptor ligands by dendritic cells. Furthermore, we have established a mouse model to characterize human dendritic cells in vivo using humanized mice in the immune system.
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| Free Research Field |
免疫学、血液学
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