2017 Fiscal Year Final Research Report
Runx-mediated regulation of chemokine CCL5 for lung diseases
| Project/Area Number |
15K08535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Seo Wooseok 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (40574116)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Keywords | アレルギー / 免疫関連疾患 |
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| Outline of Final Research Achievements |
CCL5 chemokine is related to the development of many inflammatory diseases. To understand how CCL5 is regulated, I have examined a knockout mouse of Runx/CBFβ transcription factor and discovered that CCL5 is hugely upregulated in the absence of Runx/CBFβ. This indicated that CCL5 is tightly regulated by Runx/CBFβ. By combining regular ChIP and novel enChIP assays, I discovered that CCL5 expression requires two separate enhancers depending on activation states. These enhancers are crucial for proper expression of CCL5 from T cells as well as T-cell immunity.
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| Free Research Field |
免疫学
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