2017 Fiscal Year Final Research Report
verification of suppressive effect by MCT inhibition on tumor cell growth and invasion
| Project/Area Number |
15K08581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | モノカルボン酸輸送担体（MCT） |
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| Outline of Final Research Achievements |
The aim of this study was to clarify the association between monocarboxylate transporter (MCT) 1, 4 and tumor cell growth and invasion and to identify the selective inhibitor of MCT1 or 4. This study summarizes our findings:1)At first, MCT1 or 4 is a pH-dependent transporter, is functional expressed in MCF7 or MDA-MB231 cells such as breast cancer cells. 2)MCT1 or 4 knockdown induces the reduction of these cells viability and migration compared with negative control-treated cells. 3)Fibrates and bindarit exhibit selective inhibitory effects against MCT4 compared with MCT1. These results suggest that MCT1 and 4 are associated with tumor cell viability and migration.
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| Free Research Field |
医療薬学
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