2017 Fiscal Year Final Research Report
Cisplatin conjugated gelatin hydrogel in a sustained release formulation for intraabdominal chemotherapy for peritoneal carcinomatosis
Project/Area Number |
15K08586
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
坂井 義治 京都大学, 医学研究科, 教授 (60273455)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 腹腔内化学療法 / 徐放化 / 胃癌 / 癌性腹膜炎 |
Outline of Final Research Achievements |
In this study, we have reformed our previous cisplatin sustained-release formula (gelatin microspheres incorporating CDDP: GM-CDDP) and we have developed novel formulation (gelatin hydrogel granules with incorporated cisplatin; GHG-CDDP) without using organic sorbent and which accomplished complete sustained release with only <2% initial burst. By intraperitoneal injection, good therapeutic effect was achieved with less systemic adverse effect such as body weight loss or renal toxicity in murine peritoneal carcinomatosis model.
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Free Research Field |
消化器悪性腫瘍
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