The elucidation of the predictive factor of psychological changes by chemotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Okayama University
• Principal Investigator: KITAMURA YOSHIHISA 岡山大学, 大学病院, 准教授 (40423339)
• Co-Investigator(Kenkyū-buntansha): 浅沼 幹人 岡山大学, 医歯薬学総合研究科, 教授 (00273970)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ドキソルビシン / シクロホスファミド / 化学療法 / 不安症状 / 認知機能 / 神経新生 / 脳由来神経栄養因子 / ラット

Outline of Final Research Achievements

This study investigated behavioral and biochemical changes upon treatment with doxorubicin and cyclophosphamide, focusing on mental and cognitive systems, as well as neurogenesis in male rats. The co-administration of doxorubicin and cyclophosphamide produced anxiety-like, and spatial cognitive impairments in rats. It also reduced both the number of proliferating cells in the subgranular zone of the hippocampal dentate gyrus and their survival. Serum brain-derived neurotrophic factor (BDNF) levels were decreased along with chemotherapy-induced decreases in platelet levels. However, hippocampal BDNF levels and Bdnf mRNA levels were not decreased by this treatment. These results suggest that the co-administration of doxorubicin and cyclophosphamide induces psychological and cognitive impairment, in addition to negatively affecting hippocampal neurogenesis.

Free Research Field

神経精神薬理学、精神腫瘍学、臨床薬学