2017 Fiscal Year Final Research Report
Functional expression of sensing foctors against maternal osmotic stress in the placenta
| Project/Area Number |
15K08595
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
登美 斉俊 慶應義塾大学, 薬学部(芝共立), 教授 (30334717)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 胎盤 / 胎児成長 / トランスポーター / アミノ酸 / 発現調節 |
|---|
| Outline of Final Research Achievements |
Placenta is an interface between mother and fetus and it has a role of nutrients transfer. The placenta has the function mitigating the osmotic stress exposed from maternal blood. Part of amino acid is transferred via amino acid transport system A from mother to fetus in the placenta. In this study, we clarified that expression of the system A molecule can be more quickly increased in response to the osmotic stress than other molecules and we investigated how the system A molecules is induced by hypertonic stress.
|
| Free Research Field |
生物薬剤学
|
