Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Keio University
• Principal Investigator: Hisakazu OHTANI 慶應義塾大学, 薬学部(芝共立), 教授 (70262029)
• Co-Investigator(Renkei-kenkyūsha): AKIYOSHI Takeshi 慶應義塾大学, 薬学部, 専任講師 (50399143) ; IMAOKA Ayuko 慶應義塾大学, 薬学部, 助教 (10710957)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 薬物相互作用 / 薬物代謝酵素 / 薬物トランスポータ / 代謝阻害

Outline of Final Research Achievements

The influences of genetic variation of CYP3A4 on the inhibitory kinetics of its inhibitors varied among the inhibitors and affected by the probe substrate used. The inhibitor manners (patterns) of metabolic inhibitors contained in fruit juice are different among CYP isoforms, i.e. CYP3A4, 2C9 and 2C19. The research should be focused upon the mode of inhibition that is clinically most relevant.
Using newly developed cell lines stably expressing a transporter OATP1A2 or OATP2B1, some unidentified inhibitory ingredient(s) for these transporters are considered to be contained in some fractions of grapefruit juice.

Free Research Field

臨床薬物動態学