2017 Fiscal Year Final Research Report
ANALYSIS OF THERAPEUTIC TARGET MOLECULES FOR SUSTAINED ATRIAL FIBRILLATION CAUSED BY CHRONIC VOLUME OVERLOAD
| Project/Area Number |
15K08598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
相本 恵美 東邦大学, 薬学部, 助教 (20756358)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 心房細動 / 心房拡大 / 慢性容量負荷 / アルドステロン / TRPC3チャネル |
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| Outline of Final Research Achievements |
The duration of atrial fibrillation in rats with abdominal aortocaval fistula was prolonged by chronic administration of aldosterone in a dose-dependent manner, which was effectively suppressed by an inhibitor of transient receptor potential canonical 3 (TRPC3) channels. The results may reveal that atrial remodelings caused by aldosterone administration in addition to chronic volume overload are closely associated with activation of TRPC3 channels, and it is expected that inhibitors of this channel will be applied for the therapy of atrial fibrillation.
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| Free Research Field |
医歯薬学
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