Mechanism for unpredictable drug interaction in patients with chronic kidney disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Tsujimoto Masayuki 京都薬科大学, 薬学部, 講師 (90372739)
• Co-Investigator(Kenkyū-buntansha): 峯垣 哲也 京都薬科大学, 薬学部, 助教 (10549306) ; 西口 工司 京都薬科大学, 薬学部, 教授 (80379437)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 慢性腎臓病 / 薬物代謝酵素 / 薬物トランスポーター / 薬物有害事象

Outline of Final Research Achievements

This study showed that (1) the possibility that the activity of carboxyl esterase is elevated, (2) the possibility that the function of hepatic uptake transporter (s) such as organic anion transporting polypeptide (OATP) 1B1 is decreased, (3) the possibility that the interaction mediated by OATP1B1 needs to be evaluated for each substrate, since the functional change of OATP1B1 varies depending on the substrate, (4) the possibility that enhancement of myopathy is caused not only by the increase in blood concentration but also by the enhancement of tissue toxicity of toxicity drug in patients with chronic kidney disease.

Free Research Field

臨床薬学、臨床薬理学