Roles of AGEs as exacerbation factor in pathogenesis of tissue remodeling and the development of novel targeted therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08605
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Shujitsu University
• Principal Investigator: MORI Shuji 就実大学, 薬学部, 教授 (50220009)
• Co-Investigator(Kenkyū-buntansha): 豊村 隆男 就実大学, 薬学部, 講師 (40425137) ; 渡邊 政博 就実大学, 薬学部, 助教 (10758246)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 炎症 / 組織リモデリング / サイトカイン / 分子標的

Outline of Final Research Achievements

We screened the binding factor which can interact with HMGB1 by ProtoArray analysis, and studied the pathophysiological roles of its interaction. As the result, we found that TWEAK can interact with HMGB1 with high affinity. TWEAK induced the enhancement of IL-8 mRNA expression in endothelial cells. AGEs specifically bind to TWEAK, and inhibited some inflammatory activities including TWEAK-induced IL-8 mRNA expression. These findings indicated the importance of TWEAK-AGEs interaction as novel therapeutic target molecule in the inflammatory diseases.

Free Research Field

薬理学，応用薬理学