The effect of meal content on emotional behavior: role of cannabinoid receptor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Fukuoka University
• Principal Investigator: Kenichi Mishima 福岡大学, 薬学部, 教授 (00320309)
• Co-Investigator(Kenkyū-buntansha): 入江 圭一 福岡大学, 薬学部, 助教 (50509669) ; 佐野 和憲 福岡大学, 薬学部, 講師 (50534343) ; 佐藤 朝光 福岡大学, 薬学部, 准教授 (90369025)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 大麻受容体 / 2-AG / カンナビノイド

Outline of Final Research Achievements

The 2-arachidonoylglycerol (2-AG) is an endocannabinoid that binds to cannabinoid receptor. We previously reported that hypothalamic 2-AG was increased after conditioning to the rewarding properties of HFD. In this study, we investigated the effects of HFD on the 2-AG levels and the biochemical levels. And, we also studied whether observed effects could be reversed upon removal of the HFD. As a results, HFD intake led to hyperlipidemia and liver dysfunction. And these phenotypes reversed upon removal of the HFD. While, the increment of hypothalamic 2-AG level after HFD intake did not reverse upon removal of the HFD.

Free Research Field

応用薬理学