Elucidation of mechanism on neuronal cell death and development of hemodiagnosis in ischemic stroke

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08615
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Hiroshima University
• Principal Investigator: Hosomi Naohisa 広島大学, 医歯薬保健学研究科(医), 准教授 (70363190)
• Co-Investigator(Kenkyū-buntansha): 高橋 哲也 広島大学, 病院(医), 講師 (00435942) ; 辻田 麻紀 名古屋市立大学, 大学院医学研究科, 講師 (10253262) ; 松本 昌泰 広島大学, 医歯薬保健学研究院(医), 教授 (20192346) ; 神沼 修 山梨大学, 総合研究部, 准教授 (80342921) ; 田中 茂 広島大学, 医歯薬保健学研究科(医), 講師 (20512651)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脳卒中 / バイオマーカー

Outline of Final Research Achievements

We have tried to evaluate associations of transmembrane protein 95 on neuronal physiological function and ischemic neuronal cell death for elucidating a part of mechanism of neuronal cell death in ischemic stroke, And, we aimed to develop a hemodiagnosis in acute ischemic stroke with developing quantitive assay of transmembrane protein 95. We have created several antibodies against transmembrane protein 95 to construct ELISA system. Specificity and sensitivity of those antibodies were still on analysis.

Free Research Field

脳神経内科学