Development of the early diagnostic method for diabetic nephropathy targeted to damaged mitochondrial degradation-removal system

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kitasato University
• Principal Investigator: ISHII NAOHITO 北里大学, 医療衛生学部, 教授 (80212819)
• Co-Investigator(Kenkyū-buntansha): 片桐 真人 北里大学, 医療衛生学部, 教授 (50152674)
• Co-Investigator(Renkei-kenkyūsha): YOKOBA Masanori 北里大学, 医療衛生学部, 准教授 (80316942) ; KUROSAKI Yoshifumi 北里大学, 医療衛生学部, 助教 (20602030) ; IMOTO Akemi 北里大学, 医療衛生学部, 助教 (30611230)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病性腎症 / 酸化ストレス / 損傷ミトコンドリア / マイトファジー / ニトロ化タンパク質 / 尿中ミトコンドリアタンパク質

Outline of Final Research Achievements

In the renal cortex during the normoalbuminuric stage of diabetes mellitus rats, mitophagy (mitochondrial-selective autophagy), a degradation-removal system for maintaining renal homeostasis, is induced in oxidative stress-damaged mitochondria that can cause nephropathy. The degraded mitochondrial proteins were excreted (removed) in urine.
Detection of mitochondrial proteins in the urine may represent an early diagnostic marker for diabetic nephropathy.

Free Research Field

病態検査学