2017 Fiscal Year Final Research Report
Diagnostic procedure and treatment of late recurrence and tumor dormancy
| Project/Area Number |
15K08659
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Hyogo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
本田 一文 国立研究開発法人国立がん研究センター, 研究所, ユニット長 (10260936)
菊池 正二郎 兵庫医科大学, 医学部, 准教授 (70381960)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | がん間質 / 線維芽細胞 / 休眠 / がん免疫 |
|---|
| Outline of Final Research Achievements |
We isolated cancer-associated fibroblast and normal fibroblast from advanced gastric cancer tissue. VEGF isoform and CCL2, which were secreted from fibroblasts, were concerned with a clinical course of gastric cancer patients. We performed a clinical study (UMIN 000017123) for relapsed or metastatic gastric cancer patients. It became clear that CCL2/CCR2 axis inhibition by Propagermanium improved overall survival to participate in immunopotentiative effects and tumor dormancy.
|
| Free Research Field |
外科学
|
