Role of gastrointestinal hormone in itch of atopic dermatitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Juntendo University
• Principal Investigator: TOMINAGA MITSUTOSHI 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (50468592)
• Co-Investigator(Kenkyū-buntansha): 鎌田 弥生 順天堂大学, 医学(系)研究科(研究院), 研究員(移行) (00410035) ; 高森 建二 順天堂大学, 医学部, 特任教授 (40053144)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: アロネーシス / 脊髄後角 / 後根神経節 / コレシストキニン / ドライスキン

Outline of Final Research Achievements

This study was performed to reveal the role of cholecystokinin (CCK), a　gastrointestinal hormone, in itch associated with atopic dermatitis. Pharmacologically, our behavioral analyses showed that intrathecal injection of sulfated CCK8 (CCK8S) induced alloknesis via the spinal CCK2 receptor (CCKR2). Thus, we developed a model of alloknesis, and these data suggest that the CCK8S/CCK2R system is involved in induction of alloknesis in mice.

Free Research Field

かゆみ科学、神経科学、皮膚科学

Academic Significance and Societal Importance of the Research Achievements

かゆみと掻破の悪循環を引き起こすアロネーシスの本態に迫る研究成果と、それに基づく治療法の開発が期待される。