Partial volume correction for Brain PET imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08687
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Tohoku University
• Principal Investigator: Shidahara Miho (古本美保) 東北大学, 医学系研究科, 講師 (20443070)
• Co-Investigator(Kenkyū-buntansha): 茨木 正信 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 研究員 (40360359)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 核医学 / PET / 画像処理 / 部分容積効果補正

Outline of Final Research Achievements

Partial volume effect is inevitable phenomena in positron emission tomography (PET)imaging and degrade the quantification of PET images. Partial volume correction (PVC) will improve the quantification of PET images under the perfect condition which is difficult in real clinical study. We aimed to investigate error-propagation properties of PVC algorithms and know properties of PVCs on clinical PET images.
We found that the even small error sources (eg. image-registration, segmentation), this surely propagate to the outcome and its amount is not small. In clinical data, different PVC algorithms provided difference amount of recovery and this tendency was also different among subject conditions. PVC is very sensitive with the mismatch between anatomy and PET images, so hybrid algorithms would be suitable for practical and robust PVC rather than anatomy-based method.

Free Research Field

核医学