Mendelian Randomization Analysis of Pre-diagnostic Plasma Adipokine Levels and Colorectal Cancer Risk

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cancer Center Japan
• Principal Investigator: Yamaji Taiki 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 室長 (10466203)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 大腸がん / アディポカイン / メンデルの無作為化法 / コホート研究

Outline of Final Research Achievements

Supported by Grant-in-Aid for Scientific Research C, this researcher conducted a Mendelian randomization analysis for the association of pre-diagnostic plasma adipokine levels with colorectal cancer risk. This researcher observed a positive association between plasma leptin levels and colorectal cancer risk after controlling for known confounding factors. Of interest, the Mendelian randomization analysis revealed that an observed association was not fully explained by unknown confounding factors. These results should be interpreted in light of several limitations of the Mendelian randomization analysis, and further studies are needed to confirm the findings of this study.

Free Research Field

がん疫学