2017 Fiscal Year Final Research Report

Quantitative assessment of risks of cardiovascular diseases and death attributable to chronic kidney disease

Research Project

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Project/Area Number	15K08745
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Epidemiology and preventive medicine
Research Institution	Iwate Medical University
Principal Investigator	OOSAWA MASAKI 岩手医科大学, 医学部, 非常勤講師 (60295970)
Co-Investigator(Kenkyū-buntansha)	米倉佑貴聖路加国際大学, 大学院看護学研究科, 助教 (50583845) 横山由香里日本福祉大学, 社会福祉学部, 准教授 (40632633)
Co-Investigator(Renkei-kenkyūsha)	TANNO KOZO 岩手医科大学, 医学部, 准教授 (20327026) MORINO YOSHIHIRO 岩手医科大学, 医学部, 教授 (90408063) OGASAWARA KUNIAKI 岩手医科大学, 医学部, 教授 (00305989) OBARA WATARU 岩手医科大学, 医学部, 教授 (90337155) OOMORI SO 岩手医科大学, 医学部, 教授 (20306020) OOMAMA SHINICHI 岩手医科大学, 医学部, 講師 (20453300) ITOU TOMONORI 岩手医科大学, 医学部, 教授 (30347851)
Research Collaborator	ABE TAKAYA 岩手医科大学, 医学部, 教授 (40305769)
Project Period (FY)	2015-04-01 – 2018-03-31
Keywords	慢性腎臓病 / 死亡率 / 循環器疾患罹患率 / 末期腎不全
Outline of Final Research Achievements	We conducted a prospective cohort study of 24,624 community dwellers (185,638 person-years, median 10.5 years). Crude incidence rates of outcomes (death, stroke, acute myocardial infarction (AMI), heart failure (HF) and kidney replacement therapy (KRT)) in each CKD category (2012 KDIGO CKD Guidelines (CKD stage, G1 to G4)) were estimated. Sex- and age-adjusted incidence rates and adjusted incidence rate ratios using the risk in G1 as a reference were also estimated separately by age category (middle-aged: 40 to 69 years; elderly: 70 years or older). Risks of death and stroke linearly increased with an increment of CKD category in middle-aged, risks of death, stroke and HF increased with an increment of CKD category in the elderly group. Although extremely high relative risk of KRT was observed in G4, mildly to moderately reduced kidney function contributes to considerably large increases in number of deaths and strokes.
Free Research Field	医歯薬学