Assessment of HDL levels and Risk of a First Myocardial Infarction Among Bangladeshi population: A comparison with the data of Japanese population

2015 Fiscal Year Research-status Report

• Project/Area Number: 15K08760
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: 岡崎 修 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (30203970)
• Co-Investigator(Kenkyū-buntansha): Jesmin Subrina 筑波大学, 体育系, 研究員 (60374261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 予防医学 / 心筋梗塞 / 日本 / バングラデシュ / HDL

Outline of Annual Research Achievements

We completed Ist year of this research project. We followed the time line of the research project planned during application phase. Health and Disease Research Center for Rural Peoples (HDRCRP), Dhaka, Bangladesh has played a crucial role in the implementation of current research project in Ist year. We completed a part of a case control study last year. We enrolled a total of 125 patients of acute coronary syndrome (ACS) admitted to the Coronary Care Units of Saheed Ziaur Rahman Medical College Hospital Bogra, Bangladesh. Standard definitions were used to diagnose ACS in patients who had acute myocardial infarction (MI) or unstable angina. Before starting the data collection, intensive training was provided to the hospital staffs and HDRCRP research staffs for the skilled data collection. 53.4% ACS patients had low HDL levels. STEMI-ACS patients had the highest prevalence of low HDL levels compared to non-STEMI ACS patients and the patients of unstable angina. Mean level of HDL has been found in this study population 42.1 (mg/dl). In this study we found less than 25% ACS patients had sedentary life style in Bangladesh. Mean level of BMI (kg/m2) was 22.5. Besides the highly prevalent low HDL cardiovascular disease risk factor, the 2nd common risk factor was hypertension in these ACS patients in Bangladesh.

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

The current research is on right track both from the contexts of time line and the amount of research activities scheduled to be done (100% done with target milestone achievement and implementation). Trained hospital staffs and trained research staffs could overcome all the troubles during data collection in Bangladesh. There was no big problem during data collection.

Strategy for Future Research Activity

We will continue the rest of the case control study using ACS patients in Bangladesh. This year the patients recruitment will be done at other tertiary hospitals in Bangladesh namely Rajshahi Medical College and Hospital, Rajshahi Bangladesh and Dhaka Medical College and Hospital, Dhaka, Bangladesh. We will continue biochemical investigations as well as advanced biomarkers analysis in these ACS patients dividing low and high HDL groups. Advanced statistical analysis will be done this year. Scientific manuscript will be also prepared to submit to high impact factor journal.

Causes of Carryover

Last year some biochemical reagents were donated to this study from HDRCRP, Bangladesh for lipid profile measurements. .

Expenditure Plan for Carryover Budget

The unused money for those reagents will be added to the advanced biomarker measurement this year.

Research Products

• [Int'l Joint Research] HDRCRP/Bogla Medical college/Dhaka Medical college(Bangladesh)
  • Country Name: Bangladesh
  • Counterpart Institution: HDRCRP/Bogla Medical college/Dhaka Medical college
  • # of Other Institutions: 5
• [Journal Article] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh. (2015)
  • Author(s): 1.S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
  • Journal Title: European Heart Journal Volume: 36(1) Pages: 897
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of Circulatory Levels of Endothelin-1 in Diabetic Subjects Screened Through a Cross Sectional Study from Rural Women in Bangladesh. (2015)
  • Author(s): M.A. Rahman, S. Jesmin, C.N. Mowa, F. Sohael, J. Kamiyama, A.K.M.A. Habib, N. Shimojo, M.M. Islam, M. Moroi, O. Okazaki, N. Yamaguchi, S. Kawano, T. Mizutani, Y. Iwashima
  • Journal Title: International Journal of Diabetes and Clinical Research Volume: 2 Pages: 1-5
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh. (2015)
  • Author(s): S. Jesmin, M.A. Rahman, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Journal Title: Journal of Hypertension Volume: 33 Pages: 2
  • DOI: 10.1097/01.hjh.0000469776.89393.2e
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of Circulatory Endothelin-1 Level among Preand Post-Menopausal Rural Women in Bangladesh: Result from a Population-Based Study. (2015)
  • Author(s): T. Khatun, S. Jesmin, N. Yamaguchi, J. Kamiyama, S. Akter, S.N. Sultana, M.M. Islam, O. Okazaki, S. Kawano, H. Akashi, T. Mizutani, T. Miyauchi, M.A. Rahman, A.K.M. A. Habib
  • Journal Title: Annals of Vascular Medicine and Research Volume: 2(2) Pages: 1014 (1-7)
  • DOI: 10.1016/j.lfs.2014.01.030
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assessment of Hypertension and the Associated Risk Factors in Postmenopausal Rural Women in Bangladesh: A Study from Basic Epidemiology to Biomarker Assessment. (2015)
  • Author(s): S. Jesmin, M.A. Rahman, S. Akter, M.M. Islam, T. Khatun, S.N. Sultana, S. Zaedi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Journal Title: Journal of Hypertension Volume: 33 Pages: 1
  • DOI: 10.1097/01.hjh.0000469779.86715.a9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh, (2015)
  • Author(s): S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
  • Organizer: ESC Congress 2015
  • Place of Presentation: London, United Kingdom
  • Year and Date: 2015-08-29 – 2015-09-02
  • Int'l Joint Research
• [Presentation] Nationwide Assessment of Hypertension Among the Adult Population in Bangladesh (2015)
  • Author(s): M.A. Rahman, S. Jesmin, M.M. Islam, S. Zaedi, A.S.H. Hasan, A.K.M.A. Habib, T. Khatun, S.N. Sultana, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Iwashima. A
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04 – 2015-06-07
  • Int'l Joint Research
• [Presentation] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh (2015)
  • Author(s): M.A. Rahman, S. Jesmin, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04 – 2015-06-07
  • Int'l Joint Research
• [Presentation] Assessment of Hypertension and the Associated Risk Factors in Postmenopausal Rural Women in Bangladesh: A Study from Basic Epidemiology to Biomarker Assessment (2015)
  • Author(s): M.A. Rahman, S. Jesmin, S. Akter, M.M. Islam, T. Khatun, S.N. Sultana, S. Zaedi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04 – 2015-06-07
  • Int'l Joint Research
• [Presentation] Circulatory Level of Endothelin-1 and Hypertension in Rural Women in Bangladesh: A Potential Association Evidenced From a Community Based Cross-Sectional Study (2015)
  • Author(s): M.A. Rahman, S. Jesmin, M.M. Islam, F. Sohael, A.S.H. Hasan, S. Zaedi, S.N. Sultana, N. Yamaguchi, S. Kawano, O. Okazaki, A.K.M.A. Habib
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04 – 2015-06-07
  • Int'l Joint Research