2017 Fiscal Year Annual Research Report
Assessment of HDL levels and Risk of a First Myocardial Infarction Among Bangladeshi population: A comparison with the data of Japanese population
| Project/Area Number |
15K08760
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
岡崎 修 国立研究開発法人国立国際医療研究センター, その他部局等, 第3循環器内科医長 (30203970)
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| Co-Investigator(Kenkyū-buntansha) |
Jesmin Subrina 筑波大学, 体育系, 研究員 (60374261)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 予防医学 / 心筋梗塞 / 日本 / バングラデシュ / HDL |
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| Outline of Annual Research Achievements |
At the end of the three years project, we could analyze the ACS (acute coronary syndrome) patients of 738 conducted in Bangladesh and their age and sex adjusted control subjects and this sample number is higher than expected during project application phase. Standard definitions were used to diagnose ACS in patients who had acute myocardial infarction (MI) or unstable angina. Overall low HDL prevalence was found in about 52% of these ACS patients (male 44.7% vs. female 74.3%). The prevalence of low HDL in ACS patients did not differ in rural and urban Bangladesh. Prevalence of low HDL among STEMI (Total-51.0%, Male-46.9%, Female-72.6%); among non-STEMI (Total-48.8%, Male-39.4%, Female-87.5%); among unstable angina (Total-52.0%, M-40.9%, F-72.9%) of sub groups of ACS patients. From these data, it is obviously clear that low HDL prevalence is highly dominated in female ACS patients in Bangladesh. Of note, the mean value of HDL in low HDL ACS patients did not differ among STEMI, non-STEMI and unstable angina groups. Mean level of cardiac troponin in low HDL ACS patient vs. normal HDL ACS subject was 26.6 ng/ml vs. 14.7 ng/ml (p=0.001). Prevalence of diabetes in low HDL ACS patient was the highest in non-STEMI group (22%), STEMI group (11.9%), unstable angina group (8.5%) whereas prevalence of hypertension was almost similar in STEMI (38.9%); non-STEMI (36.6%) and unstable angina (35.5%) sub groups. The ACS patients who had previous history of angina the prevalence of low HDL was 39.02%, in contrast ACS patients having previous history of myocardial infarction was 25%.
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