Role of Nrf2 in Neutrophilic Allergic Athsma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Nippon Medical School
• Principal Investigator: LI YINGJI 日本医科大学, 医学部, 准教授 (60350039)
• Co-Investigator(Kenkyū-buntansha): 川田 智之 日本医科大学, 大学院医学研究科, 大学院教授 (00224791) ; 吾妻 安良太 日本医科大学, 医学部, 教授 (10184194) ; 平田 幸代 日本医科大学, 医学部, 助手 (40322515) ; 稲垣 弘文 日本医科大学, 医学部, 講師 (50213111)
• Research Collaborator: SHIMIZU Takako
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 酸化ストレス / アレルギー / 好中球 / 気道炎症 / 喘息

Outline of Final Research Achievements

In the present study, we investigated the role of Nrf2 on an experimental model of Ovalbumin (OVA) - sensitized and challenged allergic airway inflammation in both of BALB/c and C57BL/6 mice.
Nrf2+/+ and Nrf2－/－ mice were used in both of BALB/c and C57BL/6 mice. Allergic airway inflammation was generated in the mice by intraperitoneal sensitization with OVA/alum, and the mice were challenged with OVA intranasally. The several parameters such as inflammatory cytokines, IgE, and anti-oxidation index were examined in the bronchoalveolar lavage (BAL) fluid, serum, and lung tissues.
In conclusion, the role of Nrf2 in the generation of allergic airway inflammation differs markedly between mouse strains. Our results suggest that Nrf2 may play a key role in the development of allergic airway inflammation related to neutrophils in Th2 type BALB/c mice.

Free Research Field

環境医学