2017 Fiscal Year Final Research Report
Effect of short-term and long-term exposure of asbestos on regulatory T cells
| Project/Area Number |
15K08788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Prefectural University of Hiroshima (2017)
Kawasaki Medical School (2015-2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大槻 剛巳 川崎医科大学, 医学部, 教授 (40160551)
李 順姫 川崎医科大学, 医学部, 助教 (70414026)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アスベスト / 腫瘍免疫 / アポトーシス |
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| Outline of Final Research Achievements |
Asbestos is known to cause lung cancer and malignant mesothelioma. We are proposing that asbestos inhibit tumor immune responses. In this study, we studied effect of exposure of asbestos on MT-2 as a regulatory T cell model. It was revealed that short-term exposure with high-dose asbestos induces mitochondrial dysfunction and DNA damage, and that long-term exposure of low-dose asbestos reduces transcription factor FoxP3 expression through the mechanisms independent of upstream transcription factors and DNA methylation.
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| Free Research Field |
衛生学
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