Studies on host animals for leptospirosis and hantavirus infection in Sri Lanka

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Hokkaido University
• Principal Investigator: Yoshimatsu Kumiko (吉松組子) 北海道大学, 医学研究院, 准教授 (90220722)
• Research Collaborator: Gamage Chandika D ペラデニア大学, 医学部, Senior Lecturer
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 人獣共通感染症 / ハンタウイルス感染症 / レプトスピラ / 慢性腎臓病

Outline of Final Research Achievements

To clarify the mode and host of Leptospira and hantavirus infection, rat-trapping in Sri Lanka was carried out. Pathogenic strains of Leptospires were isolated from rats and shrews. And high seroprevalence (19%) of anti-hantavirus antibody among black rats was found in rural area, Girandrukotte. In Sri Lankan endemic strain of rat was considered to be a host for Thailand virus-related hantavirus. Around 50% of chronic kidney disease by unknown etiology (CKDu) patients were seropositive to hantavirus, while 5% for healthy people in CKDu non-endemic area. In this study, in Sri Lanka, it was shown that Leptospira and hantavirus infection occurred frequently from endemic rats as the infection source, and furthermore, hantavirus infection could be the risk of progression of CKDu.

Free Research Field

国際保健