The epidemiological study for serum trans fatty acids and the incident coronary heart disease and atherosclerosis.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Osaka University
• Principal Investigator: Imano Hironori 大阪大学, 大学院医学系研究科, 准教授 (90450923)
• Co-Investigator(Kenkyū-buntansha): 平田 健一 神戸大学, 医学研究科, 教授 (20283880) ; 山岸 良匡 筑波大学, 医学医療系, 准教授 (20375504) ; 岡田 武夫 公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発, その他部局等, その他 (70450921)
• Co-Investigator(Renkei-kenkyūsha): ISO HIROYASU 大阪大学, 大学院医学系研究科, 教授 (50223053)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血清トランス脂肪酸 / トランス脂肪酸摂取量 / コホート内症例対照研究 / 横断研究 / 冠動脈疾患 / 地域住民 / ドック受診者 / 動脈硬化

Outline of Final Research Achievements

We investigated 117 cases of coronary heart disease and 234 control in nested case control study. The odds ratios of the incident coronary heart disease for each quintile group (the reference was the lowest quintile of serum trans-fatty acids (%)) was 1.24(0.59-2.61) 、1.68(0.79-3.55)、1.44(0.67-3.11)、2.03(0.95- 4.35) , respectively. However, that stepwise relation was not found in the multivariable odds ratios. We also explored the cross-sectional data of 870 men and women who had a medical check-up. Neither the score of calcification of coronary arteries nor the intra-media thickness of carotid arteries has significant relation with serum trans-fatty acids (%).

Free Research Field

循環器疾患の疫学