Metabolic profiling analysis of rat administered natural toxins

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08889
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Aichi Medical University
• Principal Investigator: OGAWA Tadashi 愛知医科大学, 医学部, 講師 (50559937)
• Co-Investigator(Kenkyū-buntansha): 財津 桂 名古屋大学, 医学系研究科, 准教授 (30700546) ; 石井 晃 名古屋大学, 医学系研究科, 教授 (30252175) ; 妹尾 洋 愛知医科大学, 医学部, 教授 (50236113)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自然毒 / GC-MS/MS / LC-QTOF-MS / 代謝物

Outline of Final Research Achievements

For the purpose of clarifying influences, toxicities and action mechanisms given by administration of natural toxins in the living body, internal metabolism profiling analyses were worked on rat. Even though establishment of connected evaluation method of metabolomics analysis and iTRAQ protein expression analysis is uncompleted, various fundamental data of metabolic profiling analyses of rat administered natural toxins were obtained by GC-MS/MS and LC-QTOF-MS.

Free Research Field

法医学