2017 Fiscal Year Final Research Report
Investigation of the mechanism of acceleration of Alzheimer disease-related neuropathology by insulin resistance
| Project/Area Number |
15K08907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
柳川 まどか 名古屋大学, 医学部附属病院, 助教 (50566982)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | インスリン抵抗性 / 認知症 / 血糖値 / グリコヘモグロビン |
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| Outline of Final Research Achievements |
Past studies suggested that insulin resistance (IR) may be involved in the mechanism of cognitive impairment in the older subjects. In the current study we studied the association of IR and cognitive function in the older subjects with mild cognitive decline. The number of 40 subjects was involved in the analysis. All the subjects had the assessments of fasting serum glucose and insulin with several cognitive assessments including Mini Mental State Examination (MMSE). The subjects were divided into 2 groups according to the score of MMSE at the cut-off of 23/24. The level of serum insulin was statistically significantly higher in the lower MMSE group than the higher group, while there was no difference in glucose and HbA1c levels. The results suggested that IR is associated with cognitive dysfunction in the older subjects.
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| Free Research Field |
老年医学
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