Randomized trial of impatient treatment for patients with anorexia nervosa and application of miRNA as a biomarker

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K08920
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kyushu University
• Principal Investigator: Takakura Shu 九州大学, 大学病院, 助教 (40532859)
• Co-Investigator(Kenkyū-buntansha): 河合 啓介 国立研究開発法人国立国際医療研究センター, その他部局等, 心療内科医長 (80325521)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 神経性やせ症 / CBT-E / 入院治療 / マイクロRNA

Outline of Final Research Achievements

The main goal of the study was to establish a standard inpatient therapy for patients with anorexia nervosa in Japan. The case supervision by one of the CBT-E (enhanced cognitive behavioral therapy) developers, which had been conducted before the beginning of the study, was continued, and 3 therapists finished the supervision.
We have developed a new inpatient therapy incorporated with the CBT-E technique to compare with conventional treatment. Twenty-one cases were finished the new impatient therapy, and 1 case is still in the treatment. Fifteen patients had prognosis without loss of body weight after discharge, and a relatively good course comparable to conventional treatment was obtained. The duration of hospitalization tended to be shortened, and a medical economic effect was also expected. Research on microRNA as a biomarker is still ongoing.

Free Research Field

心身医学

Academic Significance and Societal Importance of the Research Achievements

ANは身体的にも重症である事からも、心身医学分野において心身両面で有効な標準的治療法の開発は早急に取り組むべき課題であると考えられる。
本研究によりANに対して有効性を示す治療法が我が国ににおいて確立され、摂食障害治療拠点整備においても重要な役割を示す事が考えられる。