Study for the osteoclust-precursor-like monocyte subset on diabetic bone fragility

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08925
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Osaka City University
• Principal Investigator: MOTOYAMA Koka 大阪市立大学, 大学院医学研究科, 講師 (80382068)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / 骨粗鬆症 / 破骨前駆細胞 / 単球

Outline of Final Research Achievements

It has been demonstrated that bone fracture rate is elevated in type 2 diabetes. However, the mechanism was not fully elucidated. In this study, we investigated the involvement of altered osteoclast precursor on bone fragility in type 2 diabetes. Cortical thickness of distal radius and monocyte subsets were measured in type 2 diabetes. It revealed that CD16+ monocytes presented osteoclast marker. The rate of CD16+ monocytes is increased in lower cortical thickness group. Furthermore, the rate of CD16+ monocytes is negatively correlated with cortical thickness. The rate of CD16+ monocytes is also an independent risk factor to cortical thickness. This study elucidated possible involvement of altered proportion of CD16+ monocyte, which is one of the osteoclast precursors, on bone fragility in type 2 diabetes.

Free Research Field

糖尿病　骨粗鬆症