2017 Fiscal Year Final Research Report
Therapeutic drug monitoring for IBD
| Project/Area Number |
15K08967
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
Andoh Akira 滋賀医科大学, 医学部, 教授 (90252395)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | IBD |
|---|
| Outline of Final Research Achievements |
he present report describes a new ELISA system for measurement of serum ADA concentrations. In this system, non-specific binding of serum IgG was markedly blocked and did not require specific materials, such as anti-ADA idiotype antibodies. In addition, this study describes a novel immunoassay for AAAs that can measure AAAs in the presence of free ADA. These methods improved the diagnostic accuracy for measurement of serum ADA and AAA concentrations and might be useful for determination of the therapeutic approach for patients with a loss of response to ADA.
|
| Free Research Field |
消化器内科
|
