Development of therapeutic strategy for identification of new markers for ulcerative colitis associated colorectal cancers.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: Iwao Yasushi 慶應義塾大学, 医学部(信濃町), 教授 (40168547)
• Co-Investigator(Kenkyū-buntansha): 金井 隆典 慶應義塾大学, 医学部(信濃町), 教授 (40245478) ; 佐藤 俊朗 慶應義塾大学, 医学部(信濃町), 准教授 (70365245)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 内視鏡 / 潰瘍性大腸炎 / 大腸癌 / 幹細胞

Outline of Final Research Achievements

The number of patients with ulcerative colitis-associated colon cancer (CAC) has been increasing along with aging of patients with ulcerative colitis (UC) that became common diseases in the past decades. However, due to its rarity, it has been difficult to promote the research using human clinical samples. Thus, we have developed a research platform for rare cancer from clinical samples using establishment of organoids library that can be expanded indefinitely on demand. Furthermore, integrated analysis of genetic mutation and gene expression profile using the established sporadic colon cancer organoids and CAC organoids would enable the identification of a specific biomarker for CAC. Clonally amplified organoids enabled to perform next-generation sequencing of CAC regardless of original sample size. In particular, we developed a system which can improve the diagnostic technology of CAC by applying molecular biomarkers obtained from organoids to endoscopic and pathological analyses.

Free Research Field

消化器内科学