Role of galectin-3 and intestinal bacteria flora on NSAID-induced small intestinal ulcer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08975
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kindai University
• Principal Investigator: PARK Ah-Mee 近畿大学, 医学部, 講師 (70469245)
• Co-Investigator(Kenkyū-buntansha): 萩原 智 近畿大学, 医学部, 講師 (40460852)
• Research Collaborator: TSUNODA Ikuo 近畿大学, 医学部, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ガレクチン-3 / 腸内フローラ / NSAIDs / 小腸潰瘍

Outline of Final Research Achievements

The purpose of this study is to clarify the role of Galectin-3 (Gal3) on NSAIDs-induced intestinal ulcer. By using Gal3 knockout mice, we found that Gal-3 is a worsen factor of NSAIDs-induced intestinal ulcer. There are two possible mechanism for this negative effect of Gal3. The first one is a role of Gal3 as danger signal of activated macrophages. This molecule might cause sever inflammation. The another one is changes of intestinal bacterial flora with or without Gal-3. We found obvious differences of small intestinal flora population between wildtype mice and Gal3 mice. Those differences might affect to the ulceration by NSAIDs.

Free Research Field

炎症性疾患