2017 Fiscal Year Final Research Report
Elucidation of the mechanism of cryoglobulin formation in hepatitis C
| Project/Area Number |
15K08984
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
堤 武也 東京大学, 医科学研究所, 准教授 (00726739)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | クリオグロブリン / 自己抗原 / 自己抗体 / C型肝炎 |
|---|
| Outline of Final Research Achievements |
The component of cryoglobulin was determined in a patient with chronic hepatitis C who underwent antiviral treatment and cleared HCV RNA. Three types of antibodies concentrated in the cryoprecipitate were identified by comparing antibody profiles purified from cryoprecipitate and serum. Two of the three antibodies were autoantibodies and had cross-reactivity with HCV. Several human proteins including PAFAH1B3 were found as candidates for autoantigens. Total RNA extracted from peripheral blood specimens showed a patient-specific antibody sequence repertoire.
|
| Free Research Field |
消化器内科学
|
