2017 Fiscal Year Final Research Report
Analysis of the factors of malignant behavior in hepatic progenitor cell marker expressing hepatocellular carcinoma
| Project/Area Number |
15K08990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TERAI Shuji 新潟大学, 大学院医歯学総合研究科・消化器内科, 教授 (00332809)
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| Research Collaborator |
KOJIMA Yuichi
SEINO Satoshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 肝細胞癌 / 肝前駆細胞 / EpCAM / NCAM / CK19 / DLK1 |
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| Outline of Final Research Achievements |
In this study we analyzed the expression of four hepatic progenitor cell markers in 251 hepatocellular carcinomas (HCCs) with their clinical data and tumor markers, and significance of the hepatic progenitor markers in HCC for prognosis. We elucidated that EpCAM expression, DCP>300 mAU/ml, age > 60, Child-Pugh sore grade B or C were independent prognostic factors of poor outcome and were used in a new scoring system for HCC prognosis after operation. Expression of two or more HPC markers was a significant predictor of poor HCC outcome and co-related with AFP and AFP-L3 levels, blood vessel invasion and differentiation of the tumor.
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| Free Research Field |
肝臓病学
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