The role of BAFF in hepatocarcinogenesis in diabetes, obesity and fatty liver

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Abe Masanori 愛媛大学, 医学系研究科, 准教授 (40432786)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脂肪性肝疾患 / 肝発癌 / アディポカイン

Outline of Final Research Achievements

In this study, we analyzed the role of B cell activating factor (BAFF), which is one of adipokines, in the progression of fatty liver disease, using BAFF- and BAFF-receptor (BAFF-R) knockout (KO) mice. In a high fat diet (HFD) model, insulin resistance and adipose tissue inflammation were attenuated in both BAFF- and BAFF-R KO mice. Although hepatic steatosis and hepatocarginogenesis were improved in HFD-fed BAFF-KO mice, they were enhanced in HFD-fed BAFF-R KO mice. These findings suggest that BAFF would be a key molecule of progression, including hepatocarcinogenesis, of fatty liver disease.

Free Research Field

肝臓病学