Elucidation of the association of locomotive syndrome in chronic liver disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagasaki University
• Principal Investigator: TAURA Naota 長崎大学, 病院(医学系), 助教 (40380860)
• Co-Investigator(Kenkyū-buntansha): 有馬 和彦 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ケトン体

Outline of Final Research Achievements

OBJECTIVE:We investigated whether prognosis of patients with HCC after transcatheter arterial chemoembolization (TACE) was associated with venous blood ketone bodies. METHODS:Sixty-eight patients with HCC who underwent TACE were recruited for this study. RESULTS:The cumulative survival rate of patients with total ketone body ratio ([TKBR]: posttreatment/pretreatment total ketone bodies) <1 was 86.6%. The rate with TKBR was 59.0% at 300 d. Cox regression analysis identified the TKBR that independently and significantly predicted the patients' prognoses. Logistic regression analysis revealed the IMAC that predicted TKBR. TKBR and IMAC were positively correlated. CONCLUSIONS: The venous ketone bodies could be a new predictor of the prognosis of HCC patients after TACE.

Free Research Field

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