2017 Fiscal Year Final Research Report
Analysis and therapeutic targeting of molecular mechanisms by which hepatitis B virus evade the host innate immune response
| Project/Area Number |
15K09016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Tanaka Yasuhito 名古屋市立大学, 大学院医学研究科, 教授 (90336694)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | B型肝炎ウイルス（HBV） / 自然免疫 / 核酸センサー / インターフェロン |
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| Outline of Final Research Achievements |
In this study, we investigated the impact of HBV infection on the induction of type I and type III interferon (IFN) by stimulation of intracellular nucleic acid sensors in the hepatocytes. A HBV-permissive cell line, Hep G2-NTCP, was infected with HBV and transfected with double-strand RNA to activate nucleic acid sensors. Interestingly the induction of type I/III IFNs was significantly suppressed in the HBV-infected cells. Oh the other hand, the amounts of intracellular HBV mRNAs and extracellular viral antigen were greatly reduced in the double-strand RNA-treated group in the absence of IFNs, Thus, the activation of nucleic acid sensors induces uncharacterized antiviral pathways independent of conventional type I/III interferon signaling.
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| Free Research Field |
ウイルス学、免疫学
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