2017 Fiscal Year Annual Research Report
Development of new diagnosis shear wave methods for liver fibrosis and steatosis
| Project/Area Number |
15K09029
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
飯島 尋子 兵庫医科大学, 医学部, 教授 (80289066)
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| Co-Investigator(Kenkyū-buntansha) |
田中 真二 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420)
藤元 治朗 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 肝線維化 / 肝脂肪化 / 超音波 / shear wave / Elastography / 肝発癌リスク |
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| Outline of Annual Research Achievements |
簡便な肝線維化脂肪化診断法についての臨床研究を行った。各機種間の相関と肝線維化のゴールドスタンダードになっている機種への変換式が可能であるかの検討を肝生検と同時に施行した126名を対象とし、超音波診断装置5機種と肝硬度測定専用機（ACUSON S2000/3000、 Aixplorer、 iu22/EPIQ7、 AplioTM500、 LOGIQ E9 とFibroScanで肝硬度を測定した。 (1)平均年齢57.7歳、HBV/HCV/B+C/NBNCはそれぞれ23/63/1/40であり、 線維化stageはF1/F2/F3/F4: 54/24/32/17であった。各機種ともにF stageの上昇とともにvelocity(Vs値)も上昇し、肝硬変診断能はAUC0.95-0.98と非常に高い診断能であった。相関係数が高く回帰式の作成が可能と考え、それぞれ、FibroScanへの変換式を検討した。(2) 肝硬度測定値との関係を検討するために、VTQ（Vs値）と有意な相関関係を示す因子を検討した。F因子、Plt、アルブミン、PT-INRであり(p＜0.001)、特にF因子との相関が最も強い傾向であり、肝硬度測定値は肝線維化診断に用いられることが確認された。FibroScanとそれぞれのSWE機器の間に回帰式を使ってFibroScanへの変換式を求めた。①FibroScanとSWE-Aixplorer :TE (m/s) = 1.23 × SWE-Aixplorer (m/s) - 0.40②FibroScan とSWE-EPIQ : TE (m/s) =1.10 × SWE-EPIQ (m/s) + 0.06③ FibroScan と SWE-LOGIQ : TE (m/s) = 1.82 × SWE-LOGIQ (m/s) - 1.18④ FibroScan とSWE-ACUSON: TE (m/s) = 1.45 × SWE-ACUSON (m/s) - 0.30.⑤ FibroScan と SWE-Aplio :TE (m/s) = 1.29 × SWE-Aplio (m/s) - 0.45.今後本法を用いて非侵襲的検査法に替わる肝線維化診断法として広く普及することが望まれる。
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[Journal Article] Changes in liver stiffness and steatosis among patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response.2018
Author(s)
Kobayashi N, Iijima H, Tada T, Kumada T, Yoshida M, Aoki T, Nishimura T, Nakano C, Takata R, Yoh K, Ishii A, Takashima T, Sakai Y, Aizawa N, Nishikawa H, Ikeda N, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
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Journal Title
Eur J Gastroenterol Hepatol.
Volume: 30(5)
Pages: 546-551
DOI
Peer Reviewed
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[Journal Article] 超音波減衰法“Attenuation imaging”による新しい脂肪肝診断.2018
Author(s)
飯島 尋子, 西村 貴士, 多田 俊史, 中野 智景, 青木 智子, 高嶋 智之, 池田直人, 會澤 信弘, 西川 浩樹, 岩田 恵典, 榎本 平之, 藤元 治朗, 鹿毛 政義, 熊田 卓, 西口 修平, 矢野 博久.
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Journal Title
肝臓
Volume: 59(1)
Pages: 65-67
DOI
Peer Reviewed
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[Journal Article] Prediction of development of hepatocellular carcinoma using a new scoring system involving virtual touch quantification in patients with chronic liver diseases.2017
Author(s)
Aoki T, Iijima H, Tada T, Kumada T, Nishimura T, Nakano C, Kishino K, Shimono Y, Yoh K, Takata R, Ishii A, Takashima T, Sakai Y, Aizawa N, Nishikawa H, Ikeda N, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
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Journal Title
J Gastroenterol.
Volume: 52(1)
Pages: 104-112
DOI
Peer Reviewed
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[Journal Article] Comparison of FIB-4 index and aspartate aminotransferase to platelet ratio index on carcinogenesis in chronic hepatitis B treated with entecavir.2017
Author(s)
Nishikawa H, Nishijima N, Enomoto H, Sakamoto A, Nasu A, Komekado H, Nishimura T, Kita R, Kimura T, Iijima H, Nishiguchi S, Osaki Y.
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Journal Title
J Cancer.
Volume: 8(2)
Pages: 152-161
DOI
Peer Reviewed
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[Journal Article] Clinical implications of serum Wisteria floribunda agglutinin-positive Mac-2-binding protein in treatment-naïve chronic hepatitis B.2017
Author(s)
Ishii A, Nishikawa H, Enomoto H, Iwata Y, Kishino K, Shimono Y, Hasegawa K, Nakano C, Takata R, Nishimura T, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H, Nishiguchi S.
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Journal Title
Hepatol Res.
Volume: 47(2)
Pages: 204-215
DOI
Peer Reviewed
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[Journal Article] Proposal of a predictive model for advanced fibrosis containing Wisteria floribunda agglutinin-positive Mac-2-binding protein in chronic hepatitis C.2017
Author(s)
Nishikawa H, Takata R, Enomoto H, Kazunori Y, Kishino K, Shimono Y, Iwata Y, Hasegawa K, Nakano C, Nishimura T, Aizawa N, Sakai Y, Ikeda N, Takashima T, Ishii A, Iijima H, Nishiguchi S.
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Journal Title
Hepatol Res.
Volume: 47(3)
Pages: E74-E84
DOI
Peer Reviewed
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[Journal Article] Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases.2017
Author(s)
Nishikawa H, Nishimura T, Enomoto H, Iwata Y, Ishii A, Miyamoto Y, Ishii N, Yuri Y, Takata R, Hasegawa K, Nakano C, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Nishiguchi S, Iijima H.
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Journal Title
Nutrients.
Volume: 9(6)
Pages: E620
DOI
Peer Reviewed
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[Journal Article] Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis.2017
Author(s)
Nishikawa H, Enomoto H, Ishii A, Iwata Y, Miyamoto Y, Ishii N, Yuri Y, Takata R, Hasegawa K, Nakano C, Nishimura T, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H, Nishiguchi S.
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Journal Title
Hepatol Res.
Volume: 47(10)
Pages: 1042-1052
DOI
Peer Reviewed
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[Presentation] Enhanced patterns by intraoperative contrast-enhanced ultrasonography predicts the outcomes in patients with hepatocellular carcinoma after curative liver resection.2017
Author(s)
Ikuo Nakamura, Etsuro Hatano, Toshihiro Okada, Yasukane Asano, Uyama Naoki, Kazuhiro Suzumura, Masaharu Tada, Yuichi Kondo, Kenjiro Iida, Seikan Hai, Hideaki Iwama, Hideaki Sueoka, Hiroko Iijima, Jiro Fujimoto.
Organizer
The 68rd Annual Meeting of the American Association for the Study of Liver Diseases（AASLD2017）
Int'l Joint Research
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[Presentation] Shear wave elastography for the diagnosis of esophagogastric varices.2017
Author(s)
Hiroko Iijima, Takashi Nishimura, Chikage Nakano, Tomoko Aoki, Yuho Miyamoto Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Ryo Takata, Kazunori Yo, Akio Ishii, Tomoyuki Takashima, Yoshiyuki Sakai, Nobuhiro Aizawa, Naoto Ikeda, Hiroki Nishikawa, Yoshinori Iwata, Hirayuki Enomoto, Shuhei Nishiguchi, Jiro Fujimoto.
Organizer
UEG Week 2017
Int'l Joint Research
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