2017 Fiscal Year Final Research Report
Activation machinery of tissue-resident innate IL-5-producing cells and their roles in inflammatory diseases and fibrosis
| Project/Area Number |
15K09036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kawasaki Medical School (2016-2017)
National Center for Global Health and Medicine (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高木 智 国立研究開発法人国立国際医療研究センター, その他部局等, 免疫制御研究部長 (10242116)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 自然リンパ球 / ILC2 / 好酸球 / 炎症 / IL-5 |
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| Outline of Final Research Achievements |
Recently, novel Th2 cytokine-producing cells, type 2 innate lymphoid cells (ILC2s) were identified and analyzed as an important cells for various inflammatory diseases. In this study, we examined a role of ILC2s in liver inflammation and fibrosis with IL-5 reporter mice that we newly generated. We found that IL-5 production from ILC2s and eosinophil activation are not necessary for the development of liver inflammation and the following fibrosis. We also found that ILC2s were activated by intraperinoteal administration of oil (e.g. mineral oil and olive oil), and this activation was mediated by peritoneal cells, especially macrophages and cytokine IL-33 and/or TSLP.
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| Free Research Field |
免疫学
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