2017 Fiscal Year Final Research Report
microRNA expression during the multiple steps of pancreatic carcinogenesis
| Project/Area Number |
15K09038
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
伊地知 秀明 東京大学, 医学部附属病院, 講師 (70463841)
大塚 基之 東京大学, 医学部附属病院, 講師 (90518945)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 膵発癌 / microRNA / スプライシング |
|---|
| Outline of Final Research Achievements |
We determined the microRNA expresssion profiles in normal pnacreas tissues, PanIN tissues, and pancreatic carcinoma tissues. We found taht miR125b is increasing proportionally to the pancreatic carcinogenetic steps. In addition, miR125b trasnlocated into the nucleus when culturing the cells in three dimension and we found Galectin 3 binds to the miR125b, which may be involved in the translocation of this microRNA.Furthermore, miR125b in thenucleus was involved in the splicing of mRNAs dependeing on the sequences. These findings may be related with the pancreatic carcinogenesis by a novel pathway.
|
| Free Research Field |
膵がんの病態生理と発癌機構の解明
|
