2017 Fiscal Year Final Research Report
Identification of a molecular marker relating to the progression of pancreatic cancer cells
Project/Area Number |
15K09042
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Nakai Yousuke 東京大学, 医学部附属病院, 助教 (80466755)
|
Co-Investigator(Kenkyū-buntansha) |
山本 恵介 東京大学, 医学部附属病院, 助教 (10608532)
立石 敬介 東京大学, 医学部附属病院, 講師 (20396948)
松原 三郎 東京大学, 医学部附属病院, 助教 (40750550)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 膵癌 |
Outline of Final Research Achievements |
We reported a novel role of KDM6B in regulating PDAC progression (Carcinogenesis 2014;35(11):2404-14). KDM6B was downregulated in high grade PDACs and knockdown of KDM6B in PDAC cells increased the tumorigenicity and enhanced the aggressive phenotypes in vivo. Furthermore, CEBPA was identified as a direct target of KDM6B, and reduced KDM6B- C/EBP axis was resulted in increased aggressiveness in PDAC cells. We tried to identify a surrogate molecular marker of the cells lacking KDM6B- function. We used a cDNA microarray to compare the expression profiles of KDM6B- KD and control PDAC cells and identified the candidate molecule relating to the loss of KDM6B.
|
Free Research Field |
消化器病学
|