New endoscopic diagnosis using immunostaining and NBI in patients with IgG4-related sclerosing cholangitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: KUBOTA kensuke 横浜市立大学, 医学研究科, 教授 (70381499)
• Co-Investigator(Kenkyū-buntansha): 中島 淳 横浜市立大学, 医学研究科, 教授 (30326037)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: IgG4関連硬化性胆管炎 / 自己免疫性膵炎 / 内視鏡生検 / NBI / 肝門部胆管癌

Outline of Final Research Achievements

Endoscopic differences between proximal IgG4-SC and Klatskin tumor were studied. Cholangiography findings, endosonographic features (Narrow Band Imaging of ampulla of Vater, continuous symmetric mucosal lesion to the hilar part [CSML]), endoscopic biopsy results (bile duct and ampulla of Vater) using immunostaining were compared. For a differential diagnosis between IgG4-SC (n = 35) and Klatskin tumor (n = 47), ampullary biopsy and endoscopic findings enhanced NBI are useful in IgG4-SC. CSML were noted significantly more often in the IgG4-SC group (P < 0.01). Endoscopic features using immunostaining, NBI and CSML might provide a diagnostic clue for IgG4-SC.

Free Research Field

消化器内科学