Establishment of the biliary cancer risk assessment system using a deoxycholic acid-induced gallbladder carcinogenesis mouse model.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: Kuno Toshiya 名古屋市立大学, 大学院医学研究科, 研究員 (00345779)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 化学発癌 / 胆嚢 / 胆管

Outline of Final Research Achievements

This study was aimed to establish a gallbladder carcinogenesis mouse model for the risk assessment of the biliary tract carcinogen candidate.
In short term experiment, N-methyl-N-formylhydrazine (MFH) increased proliferative activity and the DNA damage in male ICR mouse gallbladder/biliary tract epithelium. Then, two-step gallbladder carcinogenesis experiment using MFH and deoxycholic acid administration to male ICR mice were performed. At the termination, no tumor was observed in the gallbladder/biliary tract histopathologically.
Thus, it was revealed that the meddle term MFH-deoxycholic acid exposure to ICR mouse did not have a gallbladder carcinogenic effect.

Free Research Field

実験病理学