The elucidation of the molecular mechanism about the acquisition of pancreatic cancer invasion ability and application to cancer therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09051
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kanazawa Medical University
• Principal Investigator: SHIMASAKI Takeo 金沢医科大学, 総合医学研究所, 准教授 (50377420)
• Co-Investigator(Kenkyū-buntansha): 中村 有香 金沢医科大学, 総合医学研究所, 助手 (00565632) ; 石垣 靖人 金沢医科大学, 総合医学研究所, 教授 (20232275) ; 山本 聡子 金沢医科大学, 総合医学研究所, 助手 (00768161)
• Co-Investigator(Renkei-kenkyūsha): MINAMOTO Toshinari 金沢大学, がん進展制御研究所, 教授 (50239323) ; OCHIYA Takahiro 独立行政法人国立がん研究センター, 分子細胞治療研究分野, 分野長 (60192530)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エクソソーム / 抗癌剤 / 共培養

Outline of Final Research Achievements

In biological systems, extracellular vesicles including exosomes have been recently revealed to play a significant role in the communication between various cells, and the number of papers in this subject has dramatically increased. Exosomes are only one of many key players in natural cellular interactions. Reproducing the phenomena occurring in vivo and investigating the interactions is required in order to fully examine their role. For exosome research, observing natural interactions is co-culturing technique. While the co-culturing technique has been used in many studies thus far, its application to exosomes research has been limited. Also, the relation between exosome dynamics and anti-cancer drug are uncertain.　Therefore, we analyzed about the effect of the anti-cancer agent on dynamics of exosome using new co-culture plate.

Free Research Field

腫瘍生物学