2017 Fiscal Year Final Research Report
The role of basophils in type 1 autoimmune pancreatitis.
| Project/Area Number |
15K09052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 自己免疫性膵炎 / IgG4 / 好塩基球 / M2マクロファージ |
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| Outline of Final Research Achievements |
Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. We investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP.
Basophils were detected in pancreatic tissues in 10 of 13 patients with type 1 AIP. Stimulation of TLR2 and/or TLR4, which were expressed on basophils in the pancreas, activated basophils in peripheral blood.In flow cytometric analysis, the ratios of basophils activated by TLR4 stimulation in type 1 AIP and atopic dermatitis were significantly higher than those in healthy subjects. Levels of basophils activated by TLR2 stimulation were higher in seven cases with type 1 AIP cases.Basophils activated via TLR 4 (or 2) signaling may play an important role in the pathophysiology of type 1 AIP.
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| Free Research Field |
消化器内科学
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